Myosin isoforms, muscle fiber types, and transitions
- PMID: 10998639
- DOI: 10.1002/1097-0029(20000915)50:6<500::AID-JEMT7>3.0.CO;2-7
Myosin isoforms, muscle fiber types, and transitions
Abstract
Skeletal muscle is an extremely heterogeneous tissue composed of a variety of fast and slow fiber types and subtypes. Moreover, muscle fibers are versatile entities capable of adjusting their phenotypic properties in response to altered functional demands. Major differences between muscle fiber types relate to their myosin complement, i.e., isoforms of myosin light and heavy chains. Myosin heavy chain (MHC) isoforms appear to represent the most appropriate markers for fiber type delineation. On this basis, pure fiber types are characterized by the expression of a single MHC isoform, whereas hybrid fiber type express two or more MHC isoforms. Hybrid fibers bridge the gap between the pure fiber types. The fiber population of skeletal muscles, thus, encompasses a continuum of pure and hybrid fiber types. Under certain conditions, changes can be induced in MHC isoform expression heading in the direction of either fast-to-slow or slow-to-fast. Increased neuromuscular activity, mechanical loading, and hypothyroidism are conditions that induce fast-to-slow transitions, whereas reduced neuromuscular activity, mechanical unloading, and hyperthyroidism cause transitions in the slow-to-fast direction.
Copyright 2000 Wiley-Liss, Inc.
Similar articles
-
Adult human mylohyoid muscle fibers express slow-tonic, alpha-cardiac, and developmental myosin heavy-chain isoforms.Anat Rec A Discov Mol Cell Evol Biol. 2004 Aug;279(2):749-60. doi: 10.1002/ar.a.20065. Anat Rec A Discov Mol Cell Evol Biol. 2004. PMID: 15278946
-
Coordinate changes of myosin light and heavy chain isoforms during forced fiber type transitions in rabbit muscle.Dev Genet. 1996;19(2):163-8. doi: 10.1002/(SICI)1520-6408(1996)19:23.0.CO;2-7. Dev Genet. 1996. PMID: 8900049
-
Fiber polymorphism in skeletal muscles of the American lobster, Homarus americanus: continuum between slow-twitch (S1) and slow-tonic (S2) fibers.J Exp Biol. 2004 Jul;207(Pt 16):2755-67. doi: 10.1242/jeb.01094. J Exp Biol. 2004. PMID: 15235004
-
Single muscle fiber properties in aging and disuse.Scand J Med Sci Sports. 2010 Feb;20(1):10-9. doi: 10.1111/j.1600-0838.2009.00965.x. Epub 2009 Oct 14. Scand J Med Sci Sports. 2010. PMID: 19843264 Review.
-
Response of the neuromuscular unit to spaceflight: what has been learned from the rat model.Exerc Sport Sci Rev. 1996;24:399-425. Exerc Sport Sci Rev. 1996. PMID: 8744257 Review.
Cited by
-
Contractile protein phosphorylation predicts human heart disease phenotypes.Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1644-50. doi: 10.1152/ajpheart.00957.2012. Epub 2013 Apr 5. Am J Physiol Heart Circ Physiol. 2013. PMID: 23564307 Free PMC article.
-
Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics.J Nutr Metab. 2012;2012:893876. doi: 10.1155/2012/893876. Epub 2012 Feb 29. J Nutr Metab. 2012. PMID: 22523676 Free PMC article.
-
Respiratory muscle plasticity.Compr Physiol. 2012 Apr;2(2):1441-62. doi: 10.1002/cphy.c110050. Compr Physiol. 2012. PMID: 23798306 Free PMC article. Review.
-
Evaluation of vitamin A status on myogenic gene expression and muscle fiber characteristics.J Anim Sci. 2021 Mar 1;99(3):skab075. doi: 10.1093/jas/skab075. J Anim Sci. 2021. PMID: 33693597 Free PMC article.
-
Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice-A Systematic Review.Int J Mol Sci. 2022 Oct 26;23(21):12933. doi: 10.3390/ijms232112933. Int J Mol Sci. 2022. PMID: 36361732 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
