Whole-body imaging of the musculoskeletal system: the value of MR imaging
- PMID: 17554538
- PMCID: PMC2042033
- DOI: 10.1007/s00256-007-0323-5
Whole-body imaging of the musculoskeletal system: the value of MR imaging
Abstract
In clinical practice various modalities are used for whole-body imaging of the musculoskeletal system, including radiography, bone scintigraphy, computed tomography, magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT). Multislice CT is far more sensitive than radiographs in the assessment of trabecular and cortical bone destruction and allows for evaluation of fracture risk. The introduction of combined PET-CT scanners has markedly increased diagnostic accuracy for the detection of skeletal metastases compared with PET alone. The unique soft-tissue contrast of MRI enables for precise assessment of bone marrow infiltration and adjacent soft tissue structures so that alterations within the bone marrow may be detected before osseous destruction becomes apparent in CT or metabolic changes occur on bone scintigraphy or PET scan. Improvements in hard- and software, including parallel image acquisition acceleration, have made high resolution whole-body MRI clinically feasible. Whole-body MRI has successfully been applied for bone marrow screening of metastasis and systemic primary bone malignancies, like multiple myeloma. Furthermore, it has recently been proposed for the assessment of systemic bone diseases predisposing for malignancy (e.g., multiple cartilaginous exostoses) and muscle disease (e.g., muscle dystrophy). The following article gives an overview on state-of-the-art whole-body imaging of the musculoskeletal system and highlights present and potential future applications, especially in the field of whole-body MRI.
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References
-
- {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0959-8049(97)10128-9', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0959-8049(97)10128-9'}, {'type': 'PubMed', 'value': '9741323', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/9741323/'}]}
- Rubens RD. Bone metastases: the clinical problem. Eur J Cancer 1998;34: 210–213. - PubMed
-
- {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1046/j.1365-2141.1999.01529.x', 'is_inner': False, 'url': 'https://doi.org/10.1046/j.1365-2141.1999.01529.x'}, {'type': 'PubMed', 'value': '10444160', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10444160/'}]}
- Lecouvet FE, Malghem J, Michaux L, et al. Skeletal survey in advanced multiple myeloma: radiographic versus MR imaging survey. Br J Haematol 1999;106: 35–39. - PubMed
-
- {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '11418435', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11418435/'}]}
- Daldrup-Link HE, Franzius C, Link TM, et al. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR Am J Roentgenol 2001;177: 229–236. - PubMed
-
- {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0169-5002(99)00105-1', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0169-5002(99)00105-1'}, {'type': 'PubMed', 'value': '10699692', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10699692/'}]}
- Imamura F, Kuriyama K, Seto T, et al. Detection of bone marrow metastases of small cell lung cancer with magnetic resonance imaging: early diagnosis before destruction of osseous structure and implications for staging. Lung Cancer 2000;27: 189–197. - PubMed
-
- {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1001/jama.237.23.2504', 'is_inner': False, 'url': 'https://doi.org/10.1001/jama.237.23.2504'}, {'type': 'PubMed', 'value': '576963', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/576963/'}]}
- Krishnamurthy GT, Tubis M, Hiss J, Blahd WH. Distribution pattern of metastatic bone disease. JAMA 1977;237: 837–842. - PubMed
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