Review
doi: 10.1016/j.febslet.2005.12.040.
Epub 2005 Dec 22.
A radical solution for the biosynthesis of the H-cluster of hydrogenase
Affiliations
- PMID: 16386249
- DOI: 10.1016/j.febslet.2005.12.040
Item in Clipboard
Review
A radical solution for the biosynthesis of the H-cluster of hydrogenase
FEBS Lett.
.
Free article
Abstract
Fe-only or FeFe hydrogenases, as they have more recently been termed, possess a uniquely organometallic enzyme active site, termed the H-cluster, where the electronic properties of an iron-sulfur cluster are tuned with distinctly non-biological ligands, carbon monoxide and cyanide. Recently, it was discovered that radical S-adenosylmethionine enzymes were involved in active hydrogenase expression. In the current work, we present a mechanistic scheme for hydrogenase H-cluster biosynthesis in which both carbon monoxide and cyanide ligands can be derived from the decomposition of a glycine radical. The ideas presented have broader implications in the context of the prebiotic origin of amino acids.
Similar articles
-
The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site.Science. 2008 Jul 25;321(5888):572-5. doi: 10.1126/science.1158978. Science. 2008. PMID: 18653896
-
The CO and CN(-) ligands to the active site Fe in [NiFe]-hydrogenase of Escherichia coli have different metabolic origins.FEBS Lett. 2007 Jul 10;581(17):3317-21. doi: 10.1016/j.febslet.2007.06.028. Epub 2007 Jun 21. FEBS Lett. 2007. PMID: 17597615
-
Maturation of [NiFe]-hydrogenases in Escherichia coli.Biometals. 2007 Jun;20(3-4):565-78. doi: 10.1007/s10534-006-9048-5. Epub 2007 Jan 11. Biometals. 2007. PMID: 17216401 Review.
-
Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster.Biochemistry. 2009 Jul 7;48(26):6240-8. doi: 10.1021/bi9000563. Biochemistry. 2009. PMID: 19435321
-
A third type of hydrogenase catalyzing H2 activation.Chem Rec. 2007;7(1):37-46. doi: 10.1002/tcr.20111. Chem Rec. 2007. PMID: 17304591 Review.
Cited by
-
Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold.Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10448-53. doi: 10.1073/pnas.1001937107. Epub 2010 May 24. Proc Natl Acad Sci U S A. 2010. PMID: 20498089 Free PMC article.
-
Cell-free H-cluster synthesis and [FeFe] hydrogenase activation: all five CO and CN⁻ ligands derive from tyrosine.PLoS One. 2011;6(5):e20346. doi: 10.1371/journal.pone.0020346. Epub 2011 May 31. PLoS One. 2011. PMID: 21673792 Free PMC article.
-
Self-sacrifice in radical S-adenosylmethionine proteins.Curr Opin Chem Biol. 2007 Oct;11(5):543-52. doi: 10.1016/j.cbpa.2007.08.028. Curr Opin Chem Biol. 2007. PMID: 17936058 Free PMC article. Review.
-
Crystal structure of HydF scaffold protein provides insights into [FeFe]-hydrogenase maturation.J Biol Chem. 2011 Dec 23;286(51):43944-43950. doi: 10.1074/jbc.M111.281956. Epub 2011 Nov 4. J Biol Chem. 2011. PMID: 22057316 Free PMC article.
-
Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process.J Biol Chem. 2012 Oct 19;287(43):36544-55. doi: 10.1074/jbc.M112.388900. Epub 2012 Aug 29. J Biol Chem. 2012. PMID: 22932901 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
